H2N2V1, Main, Exploration, bibRecord, 001279

Animal models in influenza vaccine testing.

Identifieur interne : 001279 ( Main/Exploration ); précédent : 001278; suivant : 001280

Animal models in influenza vaccine testing.

Auteurs : Jan Willem Van Der Laan [Pays-Bas] ; Carla Herberts ; Robert Lambkin-Williams ; Alison Boyers ; Alexander J. Mann ; John Oxford

Source :

Expert review of vaccines [ 1744-8395 ] ; 2008.

RBID : pubmed:18665776

Descripteurs français

KwdFr :
- Animaux, Furets, Humains, Infections à Orthomyxoviridae (), Macaca, Modèles animaux, Souris, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux (immunologie).
MESH :
- immunologie : Vaccins antigrippaux.
- Animaux, Furets, Humains, Infections à Orthomyxoviridae, Macaca, Modèles animaux, Souris, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.

English descriptors

KwdEn :
- Animals, Ferrets, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza Vaccines (immunology), Macaca, Mice, Models, Animal, Orthomyxoviridae Infections (prevention & control).
MESH :
- chemical , immunology : Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Ferrets, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Macaca, Mice, Models, Animal.

Abstract

The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.

DOI: 10.1586/14760584.7.6.783
PubMed: 18665776

Affiliations:

Pays-Bas

Le document en format XML

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<term>Influenza A Virus, H5N1 Subtype</term>
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<front><div type="abstract" xml:lang="en">The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.</div>
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Serveur d'exploration H2N2

Animal models in influenza vaccine testing.

Animal models in influenza vaccine testing.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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